Discovery of highly potent agents against influenza A virus.
نویسندگان
چکیده
We previously reported several new M2 inhibitors as active as amantadine against influenza A virus and validated by three types of in vitro assays. Herein, we further modified one of the most potent hits in a viral inhibition assay and conducted structure-activity relationship studies on this scaffold. As a result, compound 8e was identified to be the most potent inhibitor against wild-type influenza A virus, being nearly 240-fold more active than amantadine.
منابع مشابه
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عنوان ژورنال:
- European journal of medicinal chemistry
دوره 46 1 شماره
صفحات -
تاریخ انتشار 2011